A Novel Organ Culture Model of Mouse Intervertebral Disc Tissues
نویسندگان
چکیده
منابع مشابه
Intervertebral Disc Tissues
Cartilagenous intervertebral discs separate adjacent vertebrae in the spine, allowing modest spinal movements, and distributing compressive load evenly on the vertebral bodies. A central fluid-like nucleus pulposus region is surrounded by a tough laminated annulus fibrosus. Because adult discs lack a blood or nerve supply, cell density is very low and tissue turnover is very slow. Consequently,...
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INTRODUCTION: In vitro organ culture studies of the intervertebral disc (IVD) have been commonly used to understand the biologic and mechanical pathways contributing to disc degeneration. In particular, small animal models such as rat and rabbit have many advantages over large animals in an organ culture standpoint. Temporal and spatial stability of cell viability and extracellular matrix conte...
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STUDY TYPE Basic science Objective: Low back pain is one of the most common health problems1 and is strongly associated with intervertebral disc degeneration, (IVD). Current treatments remove the symptoms without reversing or even retarding the underlying problem. Development of new therapy for the regeneration of the degenerative IVD is complicated by the lack of a validated long-term organ ...
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Link N (DHLSDNYTLDHDRAIH) is a peptide that occurs naturally in the intervertebral discs (IVDs) and cartilage as a result of proteolytic cleavage of Link protein. Several studies have identified Link N as a growth factor capable of stimulating matrix synthesis in these tissues. We have recently discovered that annulus fibrosus cells can release an enzyme (possibly cathepsin K) that can further ...
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INTRODUCTION Back pain, a significant source of morbidity in our society, is related to the degenerative changes of the intervertebral disc. At present, the treatment of disc disease consists of therapies that are aimed at symptomatic relief. This shortcoming stems in large part from our lack of understanding of the biochemical and molecular events that drive the disease process. The goal of th...
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ژورنال
عنوان ژورنال: Cells Tissues Organs
سال: 2015
ISSN: 1422-6405,1422-6421
DOI: 10.1159/000439268